The Syro-Malabar Church teaches predestination according to the synergistic framework affirmed at the Council of Trent. God predestines the elect, but this predestination is not arbitrary or independent of foreseen faith and cooperation. God's foreknowledge includes knowledge of how each person will respond to divine grace, and God's predestinating will takes this into account.

This view, influenced by the theology of Luis de Molina (Molinism), seeks to preserve both divine sovereignty and human free will. God does not create some people for damnation; rather, God desires the salvation of all. However, some resist God's grace and ultimately reject salvation, for which they bear responsibility. God's grace is truly efficacious—it produces the desired effect—but it works through human freedom, not against it.

Double predestination (the predestination of some to damnation and others to salvation) is explicitly rejected. The church teaches that God provides sufficient grace to all for salvation, though some reject this grace. The Tridentine anathemas condemn both a Pelagian view that denies God's grace and a Calvinist view that denies human responsibility. The Syro-Malabar Church follows this middle path.