Oneness Pentecostal churches affirm that Isaiah 7:14 is a messianic prophecy fulfilled in Jesus' virgin birth. The prophecy predicts that God Himself (not a distinct second divine person) would be incarnate in human form through the Virgin Mary. The miraculous conception without a human father is affirmed as literal and historically true.

Oneness interpretation aligns with modalist theology: the verse speaks of God's miraculous self-incarnation. Jesus, as God in human form, is the fulfillment of this ancient prediction. The virgin birth is treated as essential evidence of Jesus' deity.