The Cherubim and Seraphim Church affirms the virgin birth of Jesus as predicted in Isaiah 7:14. The Church holds a high regard for Mary and her virginity, and the miraculous conception of Jesus is understood as evidence of God's divine power. This aligns with the Church's emphasis on the supernatural and miraculous character of God's work in redemption and healing.

The Cherubim and Seraphim tradition, while incorporating some African spiritual practices, maintains the classical Christian doctrine of the virgin birth. This doctrine is particularly significant in the Church's understanding of Christ's unique status as the divine-human Savior.