The Plymouth Brethren affirm Hebrews 1:8 as an explicit and unambiguous statement of Christ's full deity. In this passage, God the Father directly addresses the Son as "God," using the Greek word "theos" without qualification. The context—quoting Psalm 45:6-7 and applying it to the Son—reinforces that the Son possesses divine attributes and is worthy of divine worship. This stands as one of the clearest Old Testament prophecies of Christ's divinity, now made explicit in the New Testament.

For Brethren theology, Hebrews 1:8 is especially significant because it appears in a passage establishing Christ's superiority to angels and his role as heir of all things. The epistle's opening exegesis sets forth Christ as the radiance of God's glory and the exact representation of his being—language that leaves no room for subordinationism or denial of Christ's full equality with the Father. J.N. Darby and other Brethren commentators pointed to this verse as decisive against any Arian or Socinian reading of Scripture, affirming that Christ alone among creatures is worthy to be called God, possessing all divine perfections and eternally coexisting with the Father.