Methodists affirm that Isaiah 7:14 is a messianic prophecy fulfilled in Jesus's virgin birth, as Matthew's Gospel attests. John Wesley treated this passage as scriptural support for the virginity of Mary and the miraculous nature of Jesus's birth.

The Methodist quadrilateral supports this interpretation: Scripture teaches the virgin birth in Matthew and Luke; Christian tradition affirms it; reason accepts the possibility of divine intervention; and Christian experience finds in the incarnation a sign of God's transformative power. While Methodism does not make the mode of Jesus's conception a matter of saving doctrine, it affirms the virgin birth as biblically grounded.