The LCMS affirms that Isaiah 7:14 is a messianic prophecy of the virgin birth of Christ, directly fulfilled in Jesus's birth to the virgin Mary. The formula 'behold, a virgin shall conceive' is understood as God's sign and prophecy, cited by Matthew 1:23 as directly referring to Jesus. The LCMS doctrine of Scripture affirms the reliability of this messianic interpretation. Luther's commentary on Isaiah supports the virgin birth reading, and LCMS systematic theology integrates it into the doctrine of the incarnation.

The virgin birth is taught as an article of faith in LCMS catechesis. It affirms the reality of Christ's true humanity while maintaining the supernatural nature of his conception — a sign of God's direct action in redemption.