The Church of the Nazarene affirms Mark 16:9-20 as part of the canonical Scripture. The passage provides important testimony to Jesus's resurrection, his post-resurrection appearances, and his commission to the apostles to preach the gospel. The Nazarene theology values this passage as scriptural witness to the reality of the risen Christ.

The Nazarene approach does not engage extensively with textual-critical questions about manuscript origins; rather, the focus is on receiving the text as given in the Bible and interpreting its theological significance. Mark 16:9-20 affirms the resurrection hope and the apostolic mission that shape Nazarene faith and practice.