The Cherubim and Seraphim Church ordains pastors, prophets, and prophetesses to leadership positions. Ordination is understood as a formal setting apart and empowering by the Holy Spirit for ministerial work — preaching, prayer leadership, conducting worship services, performing baptisms and the Lord's Supper, and delivering pastoral care. The C&S does not teach sacramental priesthood in the Catholic sense; there is no sacerdotal class with power to effect grace through ritual action.

However, ordained leaders are understood as having received a special calling and anointing. Prophetesses (female prophets) hold a particularly significant role — they are expected to manifest the gifts of the Spirit, to deliver prophecies and words from the Lord, and to conduct healing and deliverance services. The white garment worn by C&S leaders symbolizes their separation to holiness and their role as mediators between the divine and human realms.

A noteworthy aspect of C&S leadership is the prominent role of women. Women can serve as pastors, prophets, and prayer house leaders. This reflects both African traditional roles of women as spiritual specialists and the early Pentecostal affirmation of women in Spirit-empowered ministry. The universal priesthood of believers is affirmed — all believers have access to God through Christ and can minister to one another — but certain individuals are formally set apart for leadership roles.