The Wesleyan Church permits blood transfusions as a matter of Christian freedom and medical necessity. The church does not interpret the biblical prohibitions against eating blood (Genesis 9:4, Leviticus 17:10-14, Acts 15:29) as forbidding lifesaving medical transfusions. These Old Testament commands were rooted in the sanctity of life and were primarily dietary prohibitions, not medical directives.

In cases of serious illness or injury where blood transfusion is medically necessary, the church affirms that a believer may receive a transfusion in good conscience. The church encourages believers to seek the best medical care available while trusting God for healing. Some Wesleyans may have personal scruples against transfusions due to conscience, and the church respects such convictions; however, no doctrinal prohibition stands against the practice. Medical decisions should be made prayerfully in consultation with believing physicians and spiritual advisors.