The Wesleyan Church affirms that the Bible is inerrant in its original autographs (the original Hebrew, Aramaic, and Greek manuscripts as first written). This means the biblical writers were preserved from error in all matters they addressed—history, science, doctrine, ethics. The church teaches that Scripture is the infallible and authoritative rule of faith and practice. However, this inerrancy pertains specifically to the original writings; the church acknowledges that ancient copying has introduced minor variations in existing manuscripts, though none affect the essential content of Christian faith.

The church's Discipline affirms the inspiration and authority of Scripture in strong terms, asserting that Scripture is 'the written Word of God' and 'the sufficient and final revelation of God's will.' This commitment to biblical authority is central to Wesleyan theology and piety. While the church affirms inerrancy, it also insists that Scripture must be interpreted with due attention to historical context, literary form, and the analogia fidei (the harmony of doctrine throughout Scripture).