The Syro-Malabar Church affirms the Chalcedonian Christology: Jesus Christ is one person with two distinct natures, divine and human, united without confusion, without change, without division, and without separation. Jesus is fully God and fully human. His divine nature is not confused with His human nature, nor is His human nature absorbed or transformed into the divine.

This two-nature, one-person formulation preserves both the full divinity of Christ and the full reality of His humanity. Jesus is the eternal Son of God, the second person of the Trinity, who took on human nature in the womb of Mary. This is why Mary can and must be called Theotokos (the mother of God), not because Mary is the mother of God's divine nature (which is impossible) but because she is the mother of the person who is God.

The Syro-Malabar tradition, expressed in the Chaldean liturgy, affirms the full personality of the risen, ascended Christ seated at the right hand of the Father. The church maintains that Christ's two natures work together in His saving work. His humanity suffered and died; His divinity sustained the sacrifice of infinite worth. The Syro-Malabar Church thus affirms the settlement at Ephesus (431 AD), which emphasizes Christ's unity as a person and Mary's status as Theotokos.