Oriental Orthodox churches affirm Isaiah 7:14 as a messianic prophecy fulfilled in the Virgin Mary and the incarnate Christ. The verse announces the Logos becoming flesh in human form through Mary's womb. This prophecy is central to Oriental Orthodox Christology and affirms Mary as Theotokos (Bearer of God).

Oriental Orthodox tradition emphasizes Mary's role as Mother of God as a theological affirmation of the Logos' full incarnation. Isaiah 7:14 is cited in liturgy and theology to affirm that what was born of Mary was the divine-human Christ, the unified incarnate expression of the Logos.