The International Church of Christ affirms Matthew 28:19 as the Great Commission and the scriptural mandate for baptism. Baptism is not merely an ordinance but is integral to salvation. The ICC teaches that baptism is the point of contact with Christ's blood and the means by which sins are forgiven. Believers are baptized into Christ and into his death and resurrection, becoming members of his body, the church.

Baptism is by immersion upon personal faith and commitment to Christ as Lord and Savior. The baptismal formula names the Trinity (or Christ's authority, depending on the understanding of the formula), and baptism marks entry into the ICC. Baptism is central to the gospel itself, not merely a response to gospel preaching.