The Coptic Orthodox Church affirms the full divinity and personhood of the Holy Spirit as the Third Person of the Trinity, co-equal and co-eternal with the Father and the Son. The Nicene-Constantinopolitan Creed is recited in its original form—'who proceeds from the Father'—without the Filioque addition. The Holy Spirit is understood to proceed from the Father alone as the single source and principle of the Godhead.

The Holy Spirit occupies a central place in Coptic sacramental theology. The epiclesis—the invocation of the Holy Spirit over the Eucharistic gifts—is one of the most solemn moments of the Coptic Divine Liturgy (St. Basil's Liturgy). Chrismation (received at baptism) is understood as the personal gift of the Holy Spirit to each believer, completing their incorporation into Christ. The Holy Spirit is also the agent through whom the saints are sanctified and through whom prayer and fasting bear spiritual fruit.