The CRCNA permits blood transfusions and recognizes no religious prohibition against this medical procedure. Unlike Jehovah's Witnesses, who refuse blood transfusions as a matter of doctrine, the CRCNA interprets biblical passages concerning blood (Leviticus 17:11, Acts 15:28–29) as addressed to specific historical contexts and not as absolute prohibitions on medical use of blood products.

The CRCNA's ethical framework emphasizes the sanctity of life and the value of medical care in preserving and extending life. Blood transfusions are understood as a legitimate medical intervention to save or extend a person's life. The CRCNA's Ethics & Religious Liberty Commission has not issued guidance restricting transfusions, and CRCNA churches and hospitals do not prohibit them.

While the CRCNA affirms the importance of informed consent and individual conscience in medical decisions, blood transfusions are not treated as a matter requiring special moral deliberation. Individual believers and families are free to accept transfusions as medically indicated without fear of violating CRCNA doctrine or discipline. The CRCNA's broader emphasis on the sanctity of human life supports the use of medical technologies like transfusion when they serve to preserve life.