Christadelphians affirm Romans 9:18-21 as expressing God's sovereign power and prerogative in matters of election and salvation. The passage is understood within Paul's argument about God's dealings with Israel and the nature of divine justice. Christadelphian theology does not sharply distinguish between predestination and free will; instead, it emphasizes God's absolute sovereignty and the necessity of human response through faith and obedience.

The potter-clay metaphor is interpreted as illustrating God's absolute authority over creation and destiny. Christadelphians understand election in terms of God's choice of a people to be His own, and this choice involves both divine foreknowledge and human response. The rejection of Israel and calling of the Gentiles is understood as part of God's sovereign historical plan.