The Brethren in Christ affirm the Protestant biblical canon of 66 books—39 in the Old Testament and 27 in the New Testament. This is the standard canon affirmed at the Reformation and by evangelical churches generally.

The denomination recognizes the Apocrypha (intertestamental Jewish writings) as historically and religiously valuable but does not affirm them as canonical Scripture with binding doctrinal authority. Some Apocryphal books (such as the Wisdom of Solomon or Ecclesiasticus) may be used devotionally or to understand Jewish thought in the Second Temple period, but they are not received as Scripture.

The canon is understood as closed: God's authoritative revelation in Scripture is complete. No additional writings should be added to the Bible or elevated to equal status with biblical books. This distinguishes the Brethren in Christ from traditions (such as the Roman Catholic or Orthodox churches) that recognize additional canonical books or (such as Latter-day Saints or Islamic traditions) that affirm additional revelations.