Biblical Unitarians uniformly reject the personhood of the Holy Spirit as a distinct third divine person of the Trinity. The Holy Spirit is understood as the power, energy, or active presence of the one God — the means by which the Father acts in creation, revelation, and the life of believers. Biblical Unitarians point to the Greek 'pneuma' (spirit, breath, wind) as fundamentally referring to divine power and activity, not a separate person.

Personifications of the Spirit in the New Testament — such as the Paraclete passages in John 14–16 — are interpreted as describing the activity of God himself (or his agent, the risen Christ) acting in and among believers, not as evidence of a distinct divine third person. The grammatical masculine of 'parakletos' is explained as a feature of the Greek word, not as evidence of personal identity.

Biblical Unitarians do affirm the reality and power of the Holy Spirit in the life of believers — God truly acts through his Spirit, regenerating, guiding, and empowering the Christian life. The disagreement is not about whether the Spirit is real and active but about whether the Spirit is a distinct divine person. Biblical Unitarians hold that the Spirit is God himself at work — not a third person alongside the Father and the Son.