Biblical Unitarian communities vary significantly in their approach to Christian holidays. Some, influenced by Christadelphian practice and the concern for biblical simplicity, avoid Christmas and Easter on the grounds that these are not New Testament observances and have pagan cultural antecedents. The central Christian observance in their view is the weekly breaking of bread — the Lord's Supper — as a weekly memorial of Christ's death.

Other Biblical Unitarian communities observe Christmas and Easter as culturally and spiritually meaningful occasions to celebrate the birth and resurrection of Christ, without making these observances theologically mandatory. The non-creedal, decentralized character of the movement means there is no ruling authority to enforce uniformity on these questions.

Colossians 2:16-17 and Romans 14:5 are commonly invoked to establish that holiday observance is a matter of personal conscience rather than doctrinal requirement. Biblical Unitarians who do observe Christmas and Easter typically emphasize the historical events — the birth of the Messiah and his resurrection — rather than any liturgical or ecclesiastical significance of the calendar dates.