The SBC has no official doctrine prohibiting blood transfusions. Southern Baptist theology does not interpret biblical passages about blood (e.g., Leviticus 17, Acts 15) as prohibitions on medical use of blood. The BFM2000's emphasis on human dignity and the sanctity of life is generally applied to support medical care, including blood transfusions, as life-preserving acts.

Unlike Jehovah's Witnesses, who refuse blood transfusions as a doctrinal commitment, Southern Baptists have no theological objection to this medical procedure. Individual medical ethics is generally left to the conscience of the believer informed by biblical principles, and the SBC's Ethics & Religious Liberty Commission (ERLC) has not issued guidance restricting blood transfusions.

The broader SBC stance on medical ethics focuses on issues such as abortion and end-of-life care, where the denomination has taken strong positions. Blood transfusions fall outside these contested areas and are treated as ordinary medical care.